Lindane is a drug used for treatment of scabies and lice but has been withdrawn from the market in many western countries due to concerns over neurotoxicity involved with the drug. Lindane acts as an organochloride insecticide.
In countries where the drug has not been banned, Lindane is not recommended to be used as a first line therapy as it may cause neurotoxicity or bone marrow suppression, but has been approved as a second line treatment for head lice (pediculosis capitis), pubic lice (pediculosis pubis) or scabies in patients over 2 years of age.
Lindane is directly absorbed through the parasite’s exoskeleton/ova. The gamma-aminobutyric acid (GABA(1)) receptor/chloride ionophore complex is the primary site of action for lindane, and other insecticides such as endosulfan, and fipronil. Blockage of the GABA-gated chloride channel reduces neuronal inhibition, which leads to hyperexcitation of the central nervous system.
There are no known drug interactions with Lindane.