Cevimeline works to alleviate symptoms of dry mouth associated with Sjögren’s syndrome. Cevimeline works as a cholinergic agonist binding to muscarinic receptors. As a muscarinic agonist, cevimeline binds and activates the muscarinic M1 and M3 receptors. M1 receptors are present in secretory glands, and the activation of these receptors results in an increase in secretions from the secretory glands. M3 receptors are found on smooth muscle  and many glands which aid stimulation of secretion in salivary glands, and so their activation will result in the contraction of smooth muscle and the increase of glandular secretions. As the excretion of saliva increases, the symptoms of dry mouth are alleviated.

 

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