Duloxetine is a drug used for ongoing treatment of major depressive disorder as well as generalised anxiety disorder. Duloxetine can also be used for treatment of neuropathic pains associated with diabetic peripheral neuropathy and fibromyalgia.

Duloxetine is a selective serotonin and norepinephrine reuptake inhibitors. A potent inhibitor of neuronal serotonin and norepinephrine reuptake, Duloxetine is a less potent inhibitor of dopamine reuptake. Duloxetine can also be used for urinary incontinence in women, by which the potentiation of serotonin and norepinephrine in the spinal cord which then increases the urethral closure forces and so involuntary urine loss is reduced. However the drug is not approved for this use in the US due to concerns over liver toxicity.