Desvenlafaxine is a serotonin norepinephrine reuptake inhibitor, an antidepressant.The drug is a synthetic form of the main major metabolite of venlafaxine, and is currently being used as the first non-hormone based treatment for alleviation of menopause symptoms. The primary use of the drug is to treat major depressive disorder.

Desvenlafaxine works by blocking the reuptake transporters for the key neurotransmitters affecting mood, and so more active neurotransmitters are left in the synapse.

Common adverse effects include nausea, hyperhidrosis, diarrhoea, dry mouth and fatigue.

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