Prednisolone is a type of steroid medication that is used to treat allergies, cancers, inflammatory conditions and autoimmune disorders. The drug can be administered by injection, as eye drops, as a topical cream or by mouth.
Prednisolone is a glucocorticoid derived from hydrocortisone. Corticosteroids work by inhibiting the inflammatory response to a variety of agents. The lipophilic structure of prednisolone helps with the easy passage of the drug through the cell membrane, where it binds to the respective glucocorticoid receptor in the cytoplasm. After binding, the GC/GCR abuses a dissociation of the chaperone proteins from the glucocorticoid receptor, enabling the translocation of the complex inside the nucleus. The GC/GCR complex binds to glucocorticoid response elements, which then results in gene inhibition/expression. Synthesis of anti-inflammatory proteins occurs by complex binding to positive glucocorticoid response elements, whereas negative glucocorticoid response elements block the transcriptions of inflammatory genes.