Domperidone (brand name Motilium) is a peripherally selective dopamine D2 receptor antagonist used to relieve symptoms of nausea and vomiting, increase gastrointestinal peristalsis and promote breast milk production.

Domperidone’s method of action for nausea relief is by blocking receptors at the chemoreceptor trigger zone (a location in the central nervous system that mediates the feeling of nausea).

Side effects can include dry mouth, diarrhoea, rash, itching and hives, as well as nausea. The drug is under scrutiny due to the link to sudden cardiac deaths, and so is only used for treatment of nausea relief and vomiting. Previously, Domperidone was used for treatment of bloating and heartburn.