Quetiapine is used as an antipsychotic medication for treatment of schizophrenia, bipolar disorder and major depressive disorder (along with an antidepressant).

Quetiapine is a dopamine, serotonin and adrenergic antagonist. Quetiapine works as a partial agonist at 5-HT1A receptors, and binds strongly to the serotonin receptors.

The use of quetiapine as a sleeping aid is not recommended, given the adverse effects associated with the drug. Some common effects include vomiting, dysphagia, backache, insomnia and abdominal pain. Rare effects can include sudden cardiac death, agranulocytosis, myocarditis and restless legs syndrome.